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This composite diagram shows the wall structure of thealimentary canal in four representative organs: esophagus stomach, small intestine, and large intestine.

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The defect in CmL manifests as dereg-ulation of proliferation, reduced adherence to the bonemarrow stroma, and abnormal response to apoptotic stimuli.CmL has an annual incidence of 1–2/100,000 individualsworldwide, and the median age at diagnosis is in the fifth orsixth decade of life.