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Instead, the knowledgegained from the examination is compared to laboratory data, imaging, vital signs, andother contributing information. Was she delirious? Did she have occasional hallucina-tions? . The elderly tend to consume more medi-cations and more classes of medications than other groupsof patients. Salt restrictionlimits edema formation and is advised in all grades of CHF.The underlying cause of CHF, if treatable like hypertension,myocardial ischaemia, valvular defects, A-V shunts,arrhythmias, thyrotoxicosis, anaemia, should be corrected.Till 1980 drugs available for CHF (digitalis and diuretics)addressed only the consequences of CHF, but not its genesis.As such, these drugs while affording symptomatic relief,did not modify the course of CHF.
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Heemstra HE, van Weely S, Buller HA, Leufkens HG, de Vrueh RL (2009) Translation ofrare disease research into orphan drug development: disease matters.