Many lifestyle factors also impinge on the cellsignaling related to endogenous defenses against OS, partic-ularly exercise, polyphenol intake, inflammatory state, obe-sity and excessive energy, and insulin resistance

Many lifestyle factors also impinge on the cellsignaling related to endogenous defenses against OS, partic-ularly exercise, polyphenol intake, inflammatory state, obe-sity and excessive energy, and insulin resistance.

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Inhalation of respiratory allergens can cause animmediate-type reaction (an early-phase reaction, occurringand waning rapidly) or a delayed-type reaction (sometimescalled a late-phase reaction), which may appear 6–8h laterand require 12–24h to resolve. In older individu-als, there is more type II collagen because of the metabolicactivity of chondrocytes, which constantly produce and dis-charge type II collagen fibrils into the surrounding matrix.In addition, the extracellular matrix of fibrocartilage con-tains larger amounts of versican (a proteoglycan monomersecreted by fibroblasts) than aggrecan (produced by chon-drocytes)

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