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Benzidine is classified as a knownhuman carcinogen by a variety of agencies and exhibitsmutagenic potential in numerous tests. Cytochromes P450: Role in the Metabolismand Toxicity of Drugs and other Xenobiotics. Hippocrates of Cos (460–370 BC) attempted trachelectomy butnoted that nothing he did could eradicate the disease.1 In the mid-fifth century, Byzantinephysician Aetius of Amida used vaginal irrigation with herbal compounds to relieve paincaused by cervical cancer.1 Ambroise Pare recommended cervical amputation, which wasperformed in 1652 by Tulpius.1 Father of American gynecology J.

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